T.C. Zhu, B. Liu, X. Liang
University of Pennsylvania, Philadelphia, PA, USA
Singlet oxygen (1O2) is the major cytotoxic agent during photodynamic therapy (PDT). A previously developed model that incorporates the diffusion equation for the light transport in tissue and the macroscopic kinetic equations for the generation of the singlet oxygen, can be used to numerically calculate the distance-dependent reacted 1O2 using finite-element method (FEM). The formula of reacted ...
P. Apell, S. Hjalmarsson, T. Lindberg, I. Wernström, Y. Tarakonov, A. Erichsen Andersson, M. Karlsteen
Department of Applied Physics, Chalmers University of Technology, Göteborg, Sweden
Sahlgrenska University Hospital, Department of Anesthesia, Surgery and Intensive Care, Göteborg, Sweden
Patients undergoing surgery are sensitive to infections. The operation staff may spread 10^4 particles per person per minute, of which ten percent are presumed bacteria-carrying. We visualize the influence of the personnel on the air and particle flows for the two most common ventilation systems in Swedish hospitals using Comsol Multiphysics with particle tracing.. The Laminar Air ...
Luleå University of Technology, Luleå, Sweden
This paper presents a numerical study of the deposition of submicron charged spherical particles caused by convection, Brownian and turbulent diffusion in a pipe with a smooth wall and with a cartilaginous ring wall structure (see figure). The model is supposed to describe deposition of charged particles in generation 0 (trachea) of the human lung.The problem is defined by solving the fluid flow ...
H. Ghosh, C. R. Chaudhuri
Department of Electronics and Telecommunication, BESUS, Howrah, West Bengal, India
In this project, we are aiming towards the development of an impedimetric biosensor based on nanoporous silicon structures for the detection of small molecular size and low weight food toxins (like Aflatoxin). Existing sensors for such toxin detection fail to achieve high sensitivity because Aflatoxin molecules are so small in size that they are unable to cause significant impedance change on the ...
Development towards Non-invasive Breast Cancer Imaging using Novel Estrogen Conjugates Fluorescent Dye
Francis .K. J., I. Jose
Christ University,Bangalore, Karnataka,India
Determination of Estrogen Receptor [ER] status is a key in detecting cancer pathogenesis at early stage. In our work we discuss Near Infrared Fluorescence [NIRf] Molecule Optical Imaging Diagnostic modality for early detection of breast cancer. A novel target-specific NIRf dye conjugate aimed at measuring Estrogen Receptor[ER] status was synthesized by ester formation between 17-? estradiol and a ...
Indian Institute of Technology Madras, Chennai, Tamil Nadu, India
Realising the interlinkage of nature and engineering are of paramount essential while comprehending the basics of system’s performances. Application of biotechniques in air pollution control is one such emerging scientific area, where the understandings of these complex systems demand more utilisation of computing softwares. Recently, biofiltration is a versatile biological air pollution ...
K. Funamoto, I.K. Zervantonakis, R.D. Kamm
Tohoku University, Sendai City, Miyagi, Japan
Massachusetts Institute of Technology
Numerical simulation of oxygen tension was performed to develop a microfluidic device for three-dimensional real-time observation of cellular response under hypoxia. The optimal experimental condition was obtained through investigations of effects of parameters, such as device thickness and flow rates of media and gas, on oxygen tension.
L. T. Izu, Z. Coulibaly, B. Peercy
University of California-Davis, Davis, CA, USA
University of Maryland, Catonsville, MD, USA
This paper utilizes the COMSOL Multiphysics® general form PDE interface and MATLAB® to model stochastic calcium waves in a sarcomere (basic unit of a heart cell). The model we present here shows the evolution of waves generated from calcium being released stochastically from sites modeled as point sources. The release sites are distributed on z-disc (planes) in a hexagonal pattern, and their ...
M. K. Gobbert, X. Huang, S. Khuvis, S. Askarian, B. E. Peercy
University of Maryland - Baltimore County, Baltimore, MD, USA
This paper presents information on techniques needed in COMSOL Multiphysics® to enable computational studies of coupled systems of PDEs for time-dependent non-linear problems. Furthermore, we demonstrate how to use data files as input for initial conditions. To illustrate the techniques, we consider a system of two time-dependent non-linear PDEs from mathematical biology that couples an ...
Comparing Isotropic and Anisotropic Brain Conductivity Modeling: Planning Optimal Depth-Electrode Placement in White Matter for Direct Stimulation Therapy in an Epileptic Circuit
L. C. Zaragoza, B. Hondorp, M. A. Rossi
ITESM, Monterrey, Mexico
Rush Medical College, Chicago, IL, USA
Rush University Medical Center, Chicago, IL, USA
The goal of our work was to calculate a patient-specific brain conductivity map for predicting the extent to which direct stimulation therapy can strategically propagate through pathological white matter. Our laboratory developed isotropic and anisotropic human brain finite element method (FEM) models derived from SPGR magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI), ...