O. Nicotra, and A. La Magna
CNR-IMM Sezione di Catania, Catania, Italy
One of the major applications for dielectrophoresis is the selective trapping and fractionation in lab-on-a-chip devices. Nevertheless, many-particle effects due to high concentrations of biological material around electrodes can cause a rapid decrease of trapping efficiency in dielectrophoretic devices. In this contribution we present a new approach based on a drift-diffusion dynamics to study ...
O. Richter, F. Suhling, and S. Moenickes
Technische Universität Braunschweig, Germany
The spatial dynamics of the invasion of new species and genetic dispersal is studied under the presumption of rising temperature by using a coherent approach of coupled partial differential equations of the reaction diffusion type. The nonlinear reaction terms model the population dynamics, genetic exchange and competition. Temperature reaction norms of reproduction rates are conferred by a two ...
Computationally Assisted Design and Experimental Validation of a Novel ‘Flow-Focussed’ Microfluidics Chip for Generating Monodisperse Microbubbles
M. Conneely, V. Hegde, H. Rolfsnes, A. Mason, D. McLean, C. Main, F.J.D. Smith, W.H.I. McLean, P.A. Campbell
Carnegie Physics Laboratory, University of Dundee, Dundee, Scotland, United Kingdom
Division of Molecular Medicine, University of Dundee, Dundee, Scotland, United Kingdom
Whilst initially developed as a diagnostic aid to improve echogenicity in ultrasound imaging, gas-filled lipid microbubbles are now emerging as a next generation \'theranostic\' tool in the medical arena. Here, their therapeutic potential has now been realized through their unique capability to deliver molecular species such as drugs and genes by means of disrupting the cell membrane in response ...
N. Mane, A. Gaikwad
Department of Instrumentation, Cummins College of Engineering, Pune, Maharashtra, India
Micro electro-mechanical system (MEMS) is rapidly growing area of interest for a broad spectrum of applications. One particularly fast-growing area is biomedical applications for micromaching technologies. One application of interest to the biomedical industry is the development of microneedles. MEMS technology brings new means for biomedicine field. Patch-based transdermal drug delivery offers ...
Estimating Cerebral Blood Flow using Electro-mechanical Modeling and Impedance Tomography Measurements
A. Jeremic, and T. Gadkari
McMaster University, Hamilton, ON, Canada
In this paper we propose a coupled electromechanical finite element model which combines the Navier-Stokes Equations of blood flow in an immersed boundary and the resulting deformed geometry with an electromagnetic model, which describes the electric field in the presence of deformation/structure changes caused by the blood flow in arteries.We derive least-squares estimates of the pressure drop ...
A. Chanda, A.R. Choudhury, G. Ray, K. Dasgupta, and D. Nag
Jadavpur University, Kolkata, West Bengal, India
Atherosclerosis in arteries is caused by the formation of stenosis : fatty depositions, on the artery wall. In current medicine, the practice is to observe the maximum percentage occlusion at any arbitrary cross-section and diagnose the patient on that basis, which might not always present the real picture due to non-uniformity of the stenosis thickness. The present work attempts to simulate the ...
A.Torrents, N. Godino, F.J. del Campo, F.X. Muñoz, and J. Mas
Universitat Autònoma de Barcelona, Spain
Microbia Fuel Cells (MFC’s) are complex environments where electrochemical, physical and biological aspects must be considered together. In this work we present a 1D model partially describing a Shewanella oneidensis MFC that degrade sodium lactate [lactate -> Acetate + CO2 + 2H+ + 2e-]. The model, simulated using COMSOL, focuses on pH implications of the MFC operation. Release of protons ...
T.C. Zhu, B. Liu, X. Liang
University of Pennsylvania, Philadelphia, PA, USA
Singlet oxygen (1O2) is the major cytotoxic agent during photodynamic therapy (PDT). A previously developed model that incorporates the diffusion equation for the light transport in tissue and the macroscopic kinetic equations for the generation of the singlet oxygen, can be used to numerically calculate the distance-dependent reacted 1O2 using finite-element method (FEM). The formula of reacted ...
Q.A. Chaudhry, M. Hanke, and R. Morgenstern
School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden
Karolinska Institutet, Stockholm, Sweden
The mathematical modeling of the diffusion and reaction of toxic compounds in mammalian cells is tough task due to their very complex geometry. The heterogeneity of the cell, particularly the cytoplasm, and the variation of the cellular architecture, greatly affects the behavior of these toxic compounds. Homogenization techniques have been implemented for the numerical treatment of the model. ...
A. K. Niemann1,5, S. A. Kock1, J. V. Nygaard2, E-T. Fründ3, S. E. Petersen4, and J. M. Hasenkam5
1 MR-center, Aarhus University Hospital Skejby, Aarhus, Denmark
2Interdisciplinary Nanoscience Center, Faculty of Science, University of Aarhus, Skejby, Denmark
3Dept. of Radiology, Aarhus University Hospital, "Aalborg Sygehus Syd", Aalborg, Denmark
4Dept. of Urology, Aarhus University Hospital Skejby, Aarhus, Denmark
5Dept. of Cardio-Thoracic and Vascular Surgery, and Clinical Institute, Aarhus University Hospital Skejby, Aarhus, Denmark
Using Computational Fluid Dynamics, different geometries of side-to-side a-v fistulas for hemodialysis access are evaluated. We created five CAD-models of fistulas with the length of the anastomosis varying from 5 to 15 mm. The five models were analyzed and evaluated using the k-ε turbulence application mode in COMSOL Multiphysics to determine if an optimal length of anastomosis exists. ...